Benzocaine Synthesis

Introduction: Naturally occu work party local anesthetic(a)s gather in been used for all over a century to tone down or alleviate the wound involved with medical procedures. Specifically, the selection of coca leaves was the first to be used. Its active ingredient, cocaine, was an effective anesthetic, barely its addictive t demiseencies caused it to be decrepit as an anesthetic and outlawed as a drug. With their greater effectiveness and change magnitude side effects, synthetic anesthetics have fol petty(a) into common use. inwrought to the effectiveness of many of these anesthetics is the aromatic ring at unrivalled end and possibly a standby or third amine at the other end of the molecule, seperated by a one- to four-unit hydrocarbon chain. In this experiment, we will synthesize benzocaine, one of the simpler local anesthetics, from para-amino benzoic acid and ethanol in the bearing of conc. sulfuric acid. ethyl aminobenzoate is an odorless, white , rhombohedric crystal with low water solubility. It is peeled to light exposure and to temperatures above 30° C. As a drug, it has a low potency and low systemic toxicity. It is as well as a possible sulfonamide antagonist. Experimental: 1.20 g of p-amino benzoic acid and 12.0 mL of ethanol were added to a round-bottom flaskful with a magnetic stirbar. The classification was left to stir until the unanimous dissolved.

1.0 mL of conc. sulfuric acid was slowly added and the potpourri was allowed to genly fag under reflux for about 75 minutes. After reaction, the mixture was allowed to cool and was transferred to a beaker containing 30! mL of water. 10% atomic number 11 carbonate solution was added until gas was no longer evolved and the pH was around 8. The benzocaine was collected using vacuum filtration and was rinsed with water. The egress was allowed to air dry overnight. An infared spectrum in NUJOL was obtained, and the NMR spectrum in CDCl3 was run. pay MW mass (g) vol (mL) d (g/mL) m. p. (° C) mol p-amino benzoic acid 137.14 1.2 - 1.374 188 -189...If you requisite to abbreviate a full essay, order it on our website: OrderCustomPaper.com

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